Coding

Part:BBa_K3003025:Design

Designed by: Merve Nida Baştürk   Group: iGEM19_Bilkent-UNAMBG   (2019-10-16)


Wild Type Insulin with a Linker Peptide (Rajpal 27)


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


Design Notes

This part was designed specifically considering the compatibility of chains with the linker sequences.


Source

Synthesized by IDT.

References

1.Fu, Z., R. Gilbert, E., & Liu, D. (2012). Regulation of Insulin Synthesis and Secretion and Pancreatic Beta-Cell Dysfunction in Diabetes. Current Diabetes Reviews, 9(1), 25–53.

2.Rajpal, G., Liu, M., Zhang, Y., & Arvan, P. (2009). Single-chain insulins as receptor agonists. Molecular endocrinology (Baltimore, Md.), 23(5), 679–688. doi:10.1210/me.2008-0349